ДЛИТЕЛЬНЫЙ НАПРАВЛЕННЫЙ ОТБОР КАК ИСТОЧНИК НАСЛЕДСТВЕННОЙ ИЗМЕНЧИВОСТИ

А. М. Марвин, К. А. Давиденко, Н. А. Марвин, Л. В. Крысова, О. Н. Антосюк

Уральский государственный университет им. А. М. Горького

Екатеринбург, Россия: kdavidenko@yandex. ru

Осуществлен длительный направленный отбор на частоту встречаемости повреж — дения крыла одновременно у двух межлинейных гибридов Drosophila melanogaster на протяжении 425 поколений с использованием мутации vestigial. Была прослежена динамика изменения генотипическойPetersburg State University, Medical Faculty

St. Petersburg, Russia: Nikita. KhromovBorisov@gmail. com

Central dogma of molecular biology (CDMB) is one of the very few biological statements, which is rather nontrivial, and cannot be deduced from physical laws. Time to time, how — ever, it is still not accepted by some authors up to the verdict that “it appeared to be more detrimental to biology than Lysencoism”. Controversies about CDMB are rather debates on the words in its formulations and on the meanings of arrows in the “Crick’s triangle”. One of the more attractable definitions of CDMB seems to be “operational” formulations proposed by John Maynard Smith: if a new (“foreign”) protein will be introduced into the cell, or some protein sequence preexisting in the cell will be modified, then such events will not result in appearance of corresponding gene, i. e. new or modified nucleotide sequence, which will be able to code that new (or modified) protein. In modern terms CDMB is an exclusion principle according to which replication, transcription and/or translation of proteins are forbidden.

Keywords: Central dogma of molecular biology, Francis Crick, John Maynard Smith, genetics, molecular biology.

Материал взят из: Чарльз Дарвин и современная биология. Труды Международной научной конференции (21–23 сентября 2009 г., Санкт — Петербург)